2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1919A
    Ajmalicine hydrochloride 4373-34-6 98%
    Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
    Ajmalicine hydrochloride
  • HY-N1924R
    Crassicauline A (Standard) 79592-91-9
    Crassicauline A (Standard) is the analytical standard of Crassicauline A. This product is intended for research and analytical applications. Crassicauline A (Crassicaulin A) is a bioactive alkaloid found in roots of Aconitum carmichaeli. Crassicauline A (Crassicaulin A) possesses feeding deterrent activity against T. castaneum adults with an EC50 of 1134.5 ppm.
    Crassicauline A (Standard)
  • HY-N1942R
    5-O-Demethylnobiletin (Standard) 2174-59-6
    5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM.
    5-O-Demethylnobiletin (Standard)
  • HY-N1966R
    (E)-Osmundacetone (Standard) 123694-03-1
    5-Aminolevulinic acid (hydrochloride) (Standard) is the analytical standard of 5-Aminolevulinic acid (hydrochloride). This product is intended for research and analytical applications. 0
    (E)-Osmundacetone (Standard)
  • HY-N1978R
    3'-Methoxypuerarin (Standard) 117047-07-1
    3'-Methoxypuerarin (Standard) is the analytical standard of 3'-Methoxypuerarin. This product is intended for research and analytical applications. 3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
    3'-Methoxypuerarin (Standard)
  • HY-N2015R
    Hastatoside (Standard) 50816-24-5
    Hastatoside (Standard) is the analytical standard of Hastatoside. This product is intended for research and analytical applications. Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep.
    Hastatoside (Standard)
  • HY-N2031R
    Parishin (Standard) 62499-28-9
    Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway.
    Parishin (Standard)
  • HY-N2038R
    3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone (Standard) 1178-24-1
    3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone (Standard) is the analytical standard of 3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone (HY-N2038). This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma.
    3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone (Standard)
  • HY-N2043R
    Huperzine B (Standard) 103548-82-9
    Huperzine B (Standard) is the analytical standard of Huperzine B. This product is intended for research and analytical applications. Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease.
    Huperzine B (Standard)
  • HY-N2071R
    Cedrol (Standard) 77-53-2
    Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
    Cedrol (Standard)
  • HY-N2079R
    (-)-Securinine (Standard) 5610-40-2
    (-)-Securinine (Standard) is the analytical standard of (-)-Securinine. This product is intended for research and analytical applications. (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
    (-)-Securinine (Standard)
  • HY-N2081R
    Skimmianine (Standard) 83-95-4
    Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca2+ signaling and protein kinase C signaling.
    Skimmianine (Standard)
  • HY-N2085R
    L-Perillaldehyde (Standard) 18031-40-8
    L-Perillaldehyde (Standard) is the analytical standard of L-Perillaldehyde. This product is intended for research and analytical applications. L-Perillaldehyde is a major component in the essential oil containing in Perillae Herba. Inhalation of L-Perillaldehyde shows antidepressant-like activity through the olfactory nervous function.
    L-Perillaldehyde (Standard)
  • HY-N2096R
    Kavain (Standard) 3155-48-4
    Kavain (Standard) is the analytical standard of Kavain. This product is intended for research and analytical applications. Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.
    Kavain (Standard)
  • HY-N2125R
    Parishin C (Standard) 174972-80-6
    Parishin C (Standard) is the analytical standard of Parishin C. This product is intended for research and analytical applications. Parishin C, a parishin derivative isolated from Gastrodia elata, may have antioxidant property.
    Parishin C (Standard)
  • HY-N2166A
    Tomatine hydrochloride 17605-83-3 98%
    Tomatine hydrochloride is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine hydrochloride elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine hydrochloride promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine hydrochloride also inhibits 20S proteasome activity.
    Tomatine hydrochloride
  • HY-N2167R
    Sibiricose A5 (Standard) 107912-97-0
    Sibiricose A5 (Standard) is the analytical standard of Sibiricose A5. This product is intended for research and analytical applications. Sibiricose A5 is an oligosaccharide ester isolated from Polygalae Radix with potent antioxidant activity.
    Sibiricose A5 (Standard)
  • HY-N2195R
    Nootkatone (Standard) 4674-50-4
    Nootkatone (Standard) is the analytical standard of Nootkatone. This product is intended for research and analytical applications. Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].
    Nootkatone (Standard)
  • HY-N2230R
    N-p-trans-Coumaroyltyramine (Standard) 36417-86-4
    N-p-trans-Coumaroyltyramine (Standard) is the analytical standard of N-p-trans-Coumaroyltyramine (HY-N2230). This product is intended for research and analytical applications. N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease.
    N-p-trans-Coumaroyltyramine (Standard)
  • HY-N2311R
    Ibotenic acid (Standard) 2552-55-8
    Sulfiram (Standard) is the analytical standard of Sulfiram. This product is intended for research and analytical applications. Sulfiram, an ectoparasiticide, is a agent applied topically to treat scabies.
    Ibotenic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity